Share on PinterestOne study found that metformin can significantly lower the risk of joint replacement in people with type 2 diabetes. Sara Hylton/Bloomberg via Getty Images Osteoarthritis is a common, chronic condition that causes pain and disability in older adults. Type 2 diabetes mellitus is a known risk factor for osteoarthritis, regardless of body mass […]
A case of relapsing HR+ metastatic breast cancer
Transcription: Jules Cohen, MD: Let’s go to clinical scenario #2. In December 2010, a 64-year-old woman with ER [estrogen receptor]–positive, PR [progesterone receptor]–negative, HER2 [human epidermal growth factor receptor 2]–negative invasive ductal carcinoma of the left breast received adjuvant anastrozole [Arimidex], presumably after all surgical and other appropriate therapies. Seventeen months later, she presents with […]
Metformin in treatment-resistant bipolar depression
RESEARCH UPDATE Treatment-resistant bipolar depression (TRBD) is defined by non-remission after 2 8-week trials of recommended medications, including combination therapy, at therapeutic doses, and associated with increased psychiatric hospitalizations and disability, and poorer quality of life.1 The prevalence of type 2 diabetes and insulin resistance in patients with bipolar disorder is about 22% and 32%, […]
Metformin for Diabetes Increases Cognitive Flexibility in Rett Mice | Benefits found in mice in advanced stages of the disease: researchers
Treatment with the diabetes drug metformin for four months led to cognitive improvements and restored brain energy production in a mouse model of Rett syndrome, according to a study. Remarkably, the therapy’s benefits were seen when administered at a relatively advanced stage of the disease – one where the mice were already affected by significant […]
Review shows that metformin use is associated with better COVID-19 outcomes
In a recent review published in Journal of Diabetes and its Complicationsresearchers reported the potential association between metformin use and the outcomes of coronavirus disease 2019 (COVID-19). Study: Metformin in SARS-CoV-2 infection: A hidden pathway – from altered inflammation to reduced mortality. A review from the literature. Image credit: bangoland/Shutterstock Background COVID-19 has led to […]
SGLT2 inhibitors may reduce cardiometabolic risk in people with diabetes using metformin
Data from a matched comparator study using data from UK primary care electronic health records offer clinicians new insight into the apparent reductions in cardiorenal risk seen with the addition of SGLT2 inhibitors to treatment algorithms for people with type 2 diabetes. 2 who already use metformin. Results of the study, which compared metformin users […]
Two popular drugs to treat type 2 diabetes performed better in large clinical trial
In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers at the University of Minnesota School of Medicine helped discover that insulin glargine and liraglutide performed better. The results were published in a pair of articles in The new English journal of medicine. The GRADE study is […]
Treatment strategies for hyperglycemia
Yehuda Handelsman, MD, FACP, FNLA, FASPC, MACE: We’ll discuss the traditional way of controlling diabetes and see what happens today. Did you want to say something? Are you with us on that 1? Jaime Murillo, MD: I’m. Yehuda Handelsman, MD, FACP, FNLA, FASPC, MACE: When we’re managing type 2 diabetes, we have to look at […]
Can This Diabetes Drug Really Slow Aging, Slow Weight Gain, Reduce Dementia? What’s behind the metformin craze?
by Lisa M. Krieger, The Mercury News </p><div> <div class=”article-gallery lightGallery”> <div data-thumb=”https://scx1.b-cdn.net/csz/news/tmb/2019/pill.jpg” data-src=”https://scx2.b-cdn.net/gfx/news/hires/2019/pill.jpg” data-sub-html=”Credit: CC0 Public Domain”> <figure class=”article-img”> <img src=”https://scx1.b-cdn.net/csz/news/800a/2019/pill.jpg” alt=”pill” title=”Credit: CC0 Public Domain” width=”800″ height=”480″/> <figcaption class=”text-darken text-low-up text-truncate-js text-truncate mt-3″> Credit: CC0 Public Domain </figcaption> </figure> </div> Is an old connection the new “panacea”? <p>Metformin, a common medication to control […]
Metformin, lifestyle changes not associated with AMD risk
A study published in JAMA Ophthalmology found that metformin use and lifestyle changes were not associated with the prevalence of age-related macular degeneration (AMD). Duration of metformin use was also not associated with AMD. AMD is the most common age-related eye condition in the United States and is a leading cause of blindness. The neovascular […]