Metaanalysis

Effectiveness of Interference Therapy in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Study collection A total of 194 articles were initially found after applying the above search terms. 17 additional articles were identified through manual search. 107 articles were subsequently identified as duplicate publications and were removed. After reviewing the titles and full texts of the remaining articles, 67 articles were identified as irrelevant articles and were […]

Meta-analysis of intravenous versus intranasal ketamine

CASE VIGNETTE “Mr King” is a 50-year-old African-American man with a history of major recurrent depressive disorder (MDD) without psychotic features. He has had partial or unresponsive or tolerability problems with multiple types of medications, including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, monoamine oxidase inhibitors, lithium, and second-generation antipsychotics. He presents at […]

Review and meta-analysis suggest that breathing can be effective for improving stress and mental health

The conclusions of a study published in Scientific Reports suggest that practicing breathing exercises helps reduce stress and improve mental health. Study: Effect of breathing on stress and mental health: a meta-analysis of randomized controlled trials. Image credit: Nata Bene/Shutterstock Background Breathing practices date back to ancient times, as evidenced in yoga (India), vessel breathing […]

Poor dental health linked to greater dementia risk: meta-analysis

Image: Shutterstock (Shutterstock) A healthy mouth may also help keep the brain healthy, new research this week suggests. The study, a broad review of the existing evidence, showed that poor dental health was linked to a later higher risk of cognitive decline and dementia. This increased risk was especially evident for those who were missing […]

Pregnancy outcomes in Takayasu arteritis patients: a systematic review and meta-analysis

Jennette, JC et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheumatism. 651–11 (2013). Article CAS Google Scholar Onen, F. & Akkoc, N. Epidemiology of Takayasu arteritis. Press. Of. 46e197–e203 (2017). Article Google Scholar Seyahi, E. Takayasu arteritis: an update. Curr. opinion. Rheumatoid. 2951-56 (2017). Article Google Scholar Merz WM, Fischer-Betz […]

Nine findings from recent meta-analysis on lung cancer screening with low-dose CT

When should surveillance chest computed tomography (CT) be discontinued for lung cancer survivors? Are incidental low-dose CT findings overdiagnosed in academic institutions? Should chronic obstructive pulmonary disease (COPD) be further considered when evaluating low-dose chest CT scans? Can artificial intelligence have an impact on improving detection rates of lung nodules on low-dose CT? In a […]

Accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression in pregnant and postpartum women: systematic review and meta-analysis of individual participant data

Acknowledgments Members of the DEPRESSD EPDS group: Chen He, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Québec, Canada; Ankur Krishnan, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Yin Wu, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; Parash Mani Bhandari, Lady Davis Institute […]

Seriously misleading network meta-analysis in Lancet of the acceptability of depression pills

ln 2018, Andrea Cipriani et al. published a network meta-analysis of depression pill trials in The Lancet. The authors included both direct drug comparisons and drug-to-placebo comparisons. They ranked the drugs according to their effect and acceptability. Acceptability was measured as dropout for any reason. This is a highly relevant outcome measure in placebo-controlled trials […]

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