Statistically significant combination against human papillomavirus infection

The prevalence of each HPV serotype included 12 high-risk human papillomaviruses (hrHPV), 2 intermediate-risk human papillomaviruses (irHPV), and 2 low-risk human papillomaviruses (lrHPV). All identifiable serotypes were indicated on the x-axis, and their proportions were indicated as percentages on the y-axis among all women infected with HPV. The left red bars indicate the 12-hour prevalence of each serotype. middle pink bars prevalence of each irHPV serotype; Right green bars prevalence of each lrHPV serotype. Credit: BGI Genomics

Human well-being has been linked to physical activity, diet balance, sleep quality, depression and anxiety. A new cross-sectional study co-authored with Dr Yantao Li, BGI Genomics, published in Frontiers in Oncologyinvestigated the relationship between these lifestyle factors and the risk of contracting human papillomavirus (HPV).

HPV is a virus that can cause various types of cancer, including cervical cancer. Most studies of risk factors for HPV focus on sexual factors or gynecological infections in women. However, there are few cross-sectional studies that account for lifestyle and other factors, current disease or history of disease. Two lifestyle factors appear to be significantly associated with HPV infection: physical activity and a balanced diet. Meanwhile, neither the current disease nor the history of the disease is closely related to HPV infection.

A total of 495 women aged 18–59 years were recruited through a digital e-health platform in Shenzhen, China, and physical activity, diet balance, and HPV infection were assessed through questionnaires and HPV genotyping screening tests.

lifestyle factors

Physical activity was assessed using self-reported questionnaires, in which participants were asked about the frequency and duration of physical activity in the past year. This data was then used to classify the participants into three levels of physical activity: low, medium, and high. The high-activity group included women who reported participating in more than 300 minutes of moderate-intensity physical activity or more than 150 minutes of vigorous physical activity per week.

As expected, patients with a high level of physical activity were less likely to be infected with HPV compared to participants with a low level of physical activity. This association was significant for P values ​​< 0.01 from the univariate logistic regression, and P values ​​< 0.001 from the multivariate logistic regression. This indicates that regular physical activity may have a protective effect against HPV infection.Diet balance was assessed using a validated food frequency questionnaire. This data was used to calculate a dietary diversity score (DDS) for each participant, which is a measure of the variety of different food groups consumed. A higher DDS indicates a more balanced diet.The study found that the prevalence of HPV infection was significantly lower in women with higher DDS compared to women with lower DDS. This suggests that a diet containing more fruits and vegetables with less fat and sugar may have a protective effect against HPV infection.

Physical activity and diet balance among human papillomavirus serotypes

Regarding HPV serotypes, the lineage prevalence included 80.66% high-risk HPV, 13.81% intermediate-risk HPV and 5.52% low-risk HPV. HPV 52 had the highest prevalence (19.89%) of the hrHPVs, followed by HPV16 (11.05%), HPV 51 (9.39%) and HPV 18 (4.42%).

Most HPV infections involved a single HPV serotype (83%), and diet balance was the most significant difference between single and multiple HPV infection. Therefore, the authors recommend two solutions to improve diet balance. Through the questionnaires of this paper, one way is to ensure adequate consumption of vitamin A dairy products and animal food products. Another way is to eat more fruits (such as tomatoes) or vegetables.

This study follows relevant regulations regarding biological and medical research and was approved by the BGI ethics committee and the relevant ethics committees of the research partners. Patients/participants provided their written informed consent to participate in this study.

more information:
Yantao Li et al, Lifestyle factors of physical activity and diet balance associated with human papillomavirus infection in China: a cross-sectional study, Frontiers in Oncology (2022). DOI: 10.3389/func.2022.1043937

Provided by BGI Genomics

the quote: Exercise and Nutrition: Statistically Significant Combination Against HPV Infection (2023, January 25) Retrieved January 25, 2023 from https://medicalxpress.com/news/2023-01-nutrition-statistically-significant-combination-hpv .html

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Statistically significant combination against human papillomavirus infection

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