Side effects, costs, uses, dosage and more

Like most medicines, Nexlizet can cause mild to serious side effects. The lists below describe some of the most common, but they do not include all possible side effects.

Keep in mind that side effects of a drug may depend on:

  • your age
  • other health problems you have
  • other medicines you are taking

Your doctor or pharmacist can tell you more about the possible side effects of Nexlizet. They can also suggest ways to help reduce side effects.

Mild side effects

Below is a list of some mild side effects that Nexlizet may cause. Talk to your doctor or pharmacist or read Nexlizet’s prescribing information for more information about other mild side effects.

Mild side effects of Nexlizet that have been reported include:

Mild side effects of many medications can go away in a few days to a few weeks. But if they become bothersome, talk to your doctor or pharmacist.

* For more information on this side effect, see the “Focus on Side Effects” section below.

Serious side effects

Serious side effects of Nexlizet can occur, but they are uncommon. If you have serious side effects of Nexlizet, contact your doctor immediately. But if you think you have a medical emergency, call 911 or your local emergency number.

Serious side effects of Nexlizet that have been reported include:

* For more information on this side effect, see the “Focus on Side Effects” section below.

Side effect focus

Read about some of the side effects that Nexlizet can cause.

Muscle cramps

Some people may experience muscle cramps while taking Nexlizet. These are sudden muscle spasms that you cannot control. Affected muscles may feel tight, hard, or painful. Most people who took Nexlizet in studies did not have this side effect. But some people had to stop taking the drug because of severe muscle cramps, although this was rare.

What might help

Muscle cramps usually go away on their own within seconds to minutes. Here are a few tips to try when a muscle cramp occurs:

  • Stretch the affected part of your body.
  • Gently massage the tight or painful area.
  • Move. For example, if leg cramps occur while lying in bed, getting up and walking around may help.

Staying hydrated can also help prevent muscle cramps. Be sure to drink plenty of fluids every day, especially if you exercise in hot weather.

Talk to your doctor if muscle cramps become severe while taking Nexlizet. They may recommend another treatment option for your condition.

Stomach ache

Some people may have stomach pain while taking Nexlizet. While most people taking the drug in studies did not have this side effect, some reported pain or discomfort in their upper or lower abdomen.

What might help

If you have abdominal pain while taking Nexlizet, it should go away with continued treatment. Some people find that taking the drug with food helps prevent or reduce this side effect. (Nexlizet can be taken with or without food.)

If this side effect does not go away or becomes severe, see your doctor. They may want to check you for other causes of abdominal pain. Or they may prescribe you another cholesterol-lowering drug instead of Nexlizet.

Tendon problems

Nexlizet contains the active substance bempedoic acid. This ingredient may increase the risk of tendon problems. (Tendons are connective tissues that attach muscle to bone.)

Pain or swelling can occur if tendons tear, tear, or become inflamed. In studies, tendon rupture occurred in the shoulders, biceps, or Achilles tendons of some people.

Certain factors may further increase the risk of tendon problems with this drug, including:

  • had a tendon rupture or injury in the past
  • be 60 years or older
  • have kidney failure
  • taking a corticosteroid medication (such as prednisone) or a fluoroquinolone antibiotic (such as ciprofloxacin)

This side effect was not specifically reported in the Nexlizet studies. But it was rare in studies that looked only at bempedoic acid, one of the active drugs in Nexlizet. (An active ingredient is what makes a drug work.)

What might help

Before you start taking Nexlizet, tell your doctor if any of the above apply to you. They may prescribe another treatment for high cholesterol that does not contain bempedoic acid. Or if you need to take a short course of a steroid or fluoroquinolone antibiotic you may need to temporarily interrupt Nexlizet treatment.

If you experience pain or swelling anywhere in your body, rest the affected area and contact your doctor immediately. They help you identify the cause of your symptoms. If they confirm you have a tendon injury, they will probably have you stop taking Nexlizet.

Allergic reaction

Some people may have an allergic reaction to Nexlizet. Allergic reactions have been reported in people taking ezetimibe, one of the active ingredients in Nexlizet.

Symptoms of a mild allergic reaction may include:

A more serious allergic reaction is rare but possible. Symptoms can include swelling under your skin, usually in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can make it difficult for you to breathe.

Call your doctor right away if you have an allergic reaction to Nexlizet. But if you think you have a medical emergency, call 911 or your local emergency number.

Side effects, costs, uses, dosage and more

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