Health assessments should consider feeding schedules for an overall picture of disease risk, researchers say

Their analysis of amino acid and metabolite concentrations in blood samples from obese or overweight patients identified striking differences in fasting and postprandial concentrations that may affect interpretations of health status.

For example, elevated levels of α-hydroxybutyrate, β-hydroxyisobutyrate, and α-ketoglutarate have been reported 60 minutes after eating a light breakfast, compared to fasting levels, and likely reflect increased postprandial amino acid catabolism. , such as glutamate and valine, which denote insulin sensitivity.

“These findings indicate that elevated concentrations of these candidate biomarkers of insulin sensitivity should be interpreted with caution if the individual’s prandial state is not known,” he said.they write in ‘BMC Nutrition’.

test protocol

Prandial status is rarely considered when analyzing biomarkers for health and disease risk, with blood typically drawn from patients fasting or after a light meal, the authors explain.

“Inconsistent observations in epidemiological studies investigating biomarkers in relation to various health and disease outcomes may be linked to differences in blood collection protocols.

“In particular, it is not clear how the time interval between the last meal and blood collection might affect blood biomarker concentrations.”

The present study, therefore, examined the effects of a bland meal on the patients’ metabolic activity (from the catabolic to the anabolic state), including serum concentrations of amino acids, kynurenine pathway metabolites, and metabolites involved in glucose regulation. The researchers also compared all biomarkers between male and female participants.

Health assessments should consider feeding schedules for an overall picture of disease risk, researchers say

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